Alcohol resistant worms and human sobriety

Alcohol resistant worms may hold key for human sobriety

Alcohol-resistant-worms-and-human-sobriety

If drinking as much alcohol as you want without getting drunk sounds like a dream, listen up: Scientists have created earthworms capable of doing just that.

If researchers can successfully recreate this development in mice and, eventually, humans, they believe it would be possible to help treat those with alcohol addiction – and one scientist even suggested the research could be used to boost espionage efforts.

These alcohol-resistant worms were created after scientists implanted various kinds of altered human alcohol targets, which bind alcohol to the brain and cause intoxication, into the animals. Researchers tested numerous kinds of these molecules to pinpoint the exact one that would allow the animals to fight off drunkenness but still continue operating normally.

“This is the first example of altering a human alcohol target to prevent intoxication in an animal,” lead researcher Jon Pierce-Shimomura of the University of Texas at Austin said to the college’s Natural Sciences website. The full study was published in the Journal of Neuroscience on Tuesday.

Ensuring that the neural channel that regulates blood vessels, the urinary tract, respiration and other functions – the BK channel – kept working properly was especially important.

“We tried a brute force approach, testing hundreds of mutations to empirically determine which one would allow the BK channel to function normally [while still] preventing alcohol from activating it,” Pierce-Shimomura added to The Verge.

“It is remarkable that [a] mutation … could have such a dramatic specific effect on ethanol modulation while minimally affecting basal BK channel function,” the study reads.

The effect was visible in the worms, too. Ingesting alcohol typically causes worms to stop wriggling around as much and slow down their movements considerably, but after scientists genetically modified them, the worms simply went about their lives as they normally would.

Moving forward, Pierce-Shimomura and his team will test their findings out in mice, which will allow them to more effectively determine if this development could help lead to drugs that would bring alcohol addiction under control. The scientist even suggested that a “James Bond” drug could be developed, which would let a spy outlast an opponent during a night of heavy drinking without getting intoxicated himself.

“Our findings provide exciting evidence that future pharmaceuticals might aim at this portion of the alcohol target to prevent problems in alcohol abuse disorders,” Pierce-Shimomura told the College of Natural Sciences. “However, it remains to be seen which aspects of these disorders would benefit.”

Still, those raising their glasses in happiness at the news may want to avoid binge-drinking for a while. Any human application for this research is unlikely to hit any time soon, if ever.

“As promising as the findings sound, it will likely be many years before they will be tested on humans,” wrote Becky Ferreria at Vice. “And as Motherboard’s Michael Byrne warned a few weeks back, ’off-switches’ for addictions may be tantalizing, but they won’t necessarily be cure-alls. For now, we’ll just have to be satisfied with the fact that the great enterprise of science has gifted the world a bunch of mutant worms that can’t get drunk.”

Source | RT

Find us here

Get news from the CSGLOBE in your inbox each weekday morning

The views and opinions expressed in this article are those of the authors/source and do not necessarily reflect the position of CSGLOBE or its staff.

Paid content

The End Of The (Petro)Dollar? Venezuela is Paying Iran In Gold For Help

With cash levels dwindling and its once mighty oil sector on its knees and needing help desperately,...

Don’t Listen to Fox. Here’s What’s Really Going On in Seattle’s Protest Zone.

It seems I live in a city undergoing a “totalitarian takeover” that will lead to “fascist outcomes”...

Five bombshells about Trump from Bolton ‘s book

Excerpts from former national security adviser John Bolton ’s book about his time in the Trump administration...

What's New Today

Georgia House Votes To Allow Citizens To Abolish Police Departments In The State

The Georgia House backed an effort on Friday to dissolve the Glynn County Police Department and any...

Leaked CDC document contradicts Pence claim that U.S. coronavirus cases ‘have stabilized’

Even as Vice President Mike Pence wrote in a Wall Street Journal op-ed published Tuesday that coronavirus...

Five bombshells about Trump from Bolton ‘s book

Excerpts from former national security adviser John Bolton ’s book about his time in the Trump administration...

Don’t Listen to Fox. Here’s What’s Really Going On in Seattle’s Protest Zone.

It seems I live in a city undergoing a “totalitarian takeover” that will lead to “fascist outcomes”...

MOST READ

What Is Agenda 21? Depopulation of 95% of the World By 2030

Most people are unaware that one of the greatest threats to their freedom may be a United Nations program which plans to depopulate 95%...

FBI ‘Mistakenly’ Releases 9/11 Bombshell In Court: Key Saudi Diplomat Who “Tasked” Hijackers Named

It’s being called “a complete government cover-up of the Saudi involvement” according to 9/11 victims’ families who...

The End Of The (Petro)Dollar? Venezuela is Paying Iran In Gold For Help

With cash levels dwindling and its once mighty oil sector on its knees and needing help desperately,...

The End Of The (Petro)Dollar? Venezuela is Paying Iran In Gold For Help

With cash levels dwindling and its once mighty oil sector on its knees and needing help desperately,...

Secret Nazi hideout discovered deep in Argentine jungle

Archaeologists explore possible Nazi hideout deep in remote Argentine jungle: report Archaeologists in Argentina believe a collection of ruins found deep in a remote jungle...

One third believe police lie routinely

Breaking down the numbers: One third of Americans believe police lie routinely Do police officers “routinely lie to serve their own interests?” Thirty-one percent of...

Google Will Help Police to Track “ Extremist Websites ”

Google Chairman “Eric Schmidt” said that they will help the police trace “extremist websites” and that legal information on Google’s search engine will be...

Nestle Just Granted Permit To Double Water Extraction 120 Miles From Flint, MI

Michigan — Nestle is at it again. Recently publicly condemned for pumping 36 million gallons of water from Strawberry Creek in the San Bernardino...

Colorado: $10 Million For Cannabis Research

Colorado Will Spend $10 Million Researching Marijuana's Medical Benefits There is an abundance of research on marijuana and its benefits, but much of it is...

The Federal Reserve and Titanic – The Connection May Surprise You?

If it were not due to this insidious privately owned organisation we would be living in a completely different world. WE DID NOT have...

Is Someone Else Making Trump’s Decisions for Him? It Certainly Seems That Way

At the end of last week, U.S. Attorney General Jeff Sessions said arresting Wikileaks founder Julian Assange is now a “priority.” Not long after, CNN...