This New Treatment Could Heal Tooth Cavities Without Any Fillings

It regrows the enamel itself.

This New Treatment Could Heal Tooth Cavities Without Any FillingsScientists have invented a new product that can encourage tooth enamel to grow back, which means we could finally have a game-changing way to treat dental cavities.

Researchers at the University of Washington have developed a treatment based on peptides – short chains of amino acids, linked by peptide bonds, that aren’t long enough to be considered full proteins.

When applied to artificially created dental lesions in a laboratory setting, the product remineralised tooth enamel, effectively “healing” the lesion.

“Remineralisation guided by peptides is a healthy alternative to current dental health care,” said materials scientist Mehmet Sarikaya.

Tooth enamel is produced by a type of cell called an ameloblast. These secrete the proteins that form enamel while the tooth is still in the gum.

Unfortunately, once the process of forming tooth enamel is complete and the tooth has emerged, our ameloblasts die off. But we continue to lose enamel throughout our lifetime.

“Bacteria metabolise sugar and other fermentable carbohydrates in oral environments and acid, as a by-product, will demineralise the dental enamel,” said dentistry researcher Sami Dogan.

To a small extent, our teeth can be remineralised with the help of saliva, fluoride toothpaste and drinking water additives.

But once there’s a visible cavity on the tooth, it needs to be treated by a dentist – which usually means drilling, and packing the hole with a dental filling.

To develop their new treatment, the team turned to one of the proteins produced by ameloblasts. Called amelogenins, these proteins play a key role in regulating the formation of tooth enamel.

The team designed peptides based on this protein and created a treatment with the peptide as an active ingredient.

They applied it to dental lesions in a laboratory setting and found that it helped form a new mineralised layer to the demineralised areas, integrating it with the enamel underneath.

This New Treatment Could Heal Tooth Cavities Without Any Fillings 2
ACS Publications

They also treated similar lesions with fluoride, but only the peptide treatment resulted in the remineralisation of a relatively thick layer – resembling the structure of healthy enamel.

Tests still need to be undertaken to see of the peptide solution works as well as it does in a living mouth as it did in the laboratory.

And for deep cavities that reach the dentine layer underneath the enamel, a filling would still likely be required.

But the researchers believe their product could be sold as part of a preventative everyday tooth care routine, in the form of a toothpaste or gel, to help minimise expensive trips to the dentist for shallower cavities.

“Peptide-enabled formulations will be simple and would be implemented in over-the-counter or clinical products,” Sarikaya said.

The team has published their research in the journal ACS Biomaterials Science & Engineering.

Find us here

Get news from the CSGLOBE in your inbox each weekday morning

The views and opinions expressed in this article are those of the authors/source and do not necessarily reflect the position of CSGLOBE or its staff.

Paid content

Oklahoma High Schooler’s Carbon Discovery Elicits Wonder From Experts

Taking teenage rebellion to a new level, Oklahoma high school senior George Wang stunned teachers and fellow students when in April he co-authored a...

NASA offering $18,000 for human lab rats to stay in bed

Nasa pays $18,000 to allow human lab rats to stay in bed for 70 days and nights NASA will pay $18,000 to anyone prepared to...

Winter is coming: Earth awaits ‘mini ice age’ in 15 years, solar cycle study suggests

Earth is facing the prospect of a ‘mini ice age’ this century, with our sun’s activity projected to fall 60 percent in the 2030s,...

What's New Today

Georgia House Votes To Allow Citizens To Abolish Police Departments In The State

The Georgia House backed an effort on Friday to dissolve the Glynn County Police Department and any...

Leaked CDC document contradicts Pence claim that U.S. coronavirus cases ‘have stabilized’

Even as Vice President Mike Pence wrote in a Wall Street Journal op-ed published Tuesday that coronavirus...

Five bombshells about Trump from Bolton ‘s book

Excerpts from former national security adviser John Bolton ’s book about his time in the Trump administration...

Don’t Listen to Fox. Here’s What’s Really Going On in Seattle’s Protest Zone.

It seems I live in a city undergoing a “totalitarian takeover” that will lead to “fascist outcomes”...

MOST READ

What Is Agenda 21? Depopulation of 95% of the World By 2030

Most people are unaware that one of the greatest threats to their freedom may be a United Nations program which plans to depopulate 95%...

Bombs Have Been Dropped in Nevada – U.S. is Responsible

Apparently, America is now using Nevada's land to test bombs. With each passing day, the U.S. continues to follow their own personal agenda. A report did reveal...

Oklahoma High Schooler’s Carbon Discovery Elicits Wonder From Experts

Taking teenage rebellion to a new level, Oklahoma high school senior George Wang stunned teachers and fellow students when in April he co-authored a...

Oklahoma High Schooler’s Carbon Discovery Elicits Wonder From Experts

Taking teenage rebellion to a new level, Oklahoma high school senior George Wang stunned teachers and fellow students when in April he co-authored a...

Accidental discovery of blood, collagen in dinosaur bones could rewrite textbooks

An amazing discovery could rewrite textbooks, after a paleontologist accidentally found blood and soft tissue preserved in tattered dinosaur fossils. If proven, science expects...

Peer-Reviewed Science Losing Credibility As Large Amounts Of Research Are Found To Be False

Although good science should always be reviewed, using this label as a form of credibility can be dangerous, causing people to dismiss new information...

Study Reveals Cannabis May Offer a Breakthrough Treatment for Alzheimer’s

A study out of the Salk Institute for Biological Studies in California has demonstrated that the psychoactive compound in cannabis, tetrahydrocannabinol (THC), removes clumps of...

Most “honey” From Grocery Stores Is Not Actually Honey

It seems that corporations just can’t leave well enough alone. Even something as natural and historically revered as honey has to be processed until...

Mystery of China’s Terracotta Army Finally Solved

The 2,000-Year-Old Mystery of China’s Terracotta Army Has Finally Been Solved Every member of First Emperor Qin Shihuang’s Terracotta Army —thousands of replicas of Chinese...

Children Now Face Fines & Arrest If They Don’t Get a Permit to Mow Grass for Money

A regular summer right of passage for motivated teenagers across the United States in search of some extra spending money has always been cutting...

How filming police could get you arrested

NY State Candidate for Governor Arrested For Filming Police Despite the Supreme Court having ruled that videotaping police is legal and protected by the 1st...