Honey Kills A Wide Range of Cancers
The review focused on the potential of honey to affect a variety of cancers, including:
- Liver Cancer: Gelam honey has been found to kill liver cancer cells, exhibiting selective cytotoxicity, anti-angiogenic, cytotoxic, and anti-proliferative properties, in both cell and animal research.
- Colorectal Cancer: gelam and nenas monofloral honeys exhibit anti-cancer properites in colorectal cell lines.
- Prostate Cancer: Greek honeys (thyme, pine and fir honey) have been found to exhibit anti-proliferative properties.
- Other Forms of Cancer: There has been a battery of studies on the anti-cancer properties of honey, focusing on the following types: a) bladder b) endometrial c) renal cell carcinoma d) skin cancer cells e) cervical f) non-small cell lung cancer g) mouth cancer h) bone cancer (osteosarcoma).[/checklist]
What are the Mechanisms of Honey Anticancer Properties?
There are a wide range of observed mechanisms of honey’s cancer-killing properties, which include:
- Cell Cycle Arrest – The normal process of cancer cell replication is halted.
- Activation of the Mitochondrial Pathway – compounds or agents such as honey rich in flavonoids that are capable of activating mitochondrial pathway and release of proteins such as cytochrome C are considered potential cytotoxic (cell killing) agents.
- Induction of Mitochondrial Outer Membrane Permeabilization – The induction of mitochondrial outer membrane permeabilization (MOMP) leads to leakage of intermembrane space proteins into the cytosol and consequently causing cell death.
- Induction of Programmed Cell Death (Apoptosis): The activation of a “cell death” program designed to protect against cancer.
- Modulation of Oxidative Stress: It is believed that honey’s antioxidant properties may nip one of the fundamental processes in cancer’s progression – oxidative stress – in the bud.
- Amelioration of Inflammation: Inflammation is at the root of many cancers, and since honey is able to suppress it, it is can significant impact carcinogenesis.
- Modulation of Insulin Signaling: Because cancer is associated with increased insulin resistance and honey is capable of reducing insulin resistance, it is believed to mitigate a major driving factor in carcinogenesis.
- Inhibition of Angiogenesis: Honey has been found to inhibit the fundamental process of cancer expansion (the production of a new blood supply) by inhibiting angiogenesis.[/checklist]
The study reviewed all possible avenues through which honey suppressed cancer, with 20 depicted in the image below:
The study concluded with following summarization:
[box type=”info” ]Honey is a natural product that shows potential effects to inhibit or suppress the development and progression of tumor and cancer. Its antiproliferative, antitumor, antimetastic and anticancer effects are mediated via diverse mechanisms, including cell cycle arrest, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling, and inhibition of angiogenesis in cancer cells. Honey is highly and selectively cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. It can inhibit cancerogenesis by modulating or interfering with the molecular processes or events of initiation, promotion, and progression stages. It, therefore, can be considered a potential and promising anticancer agent which warrants further research—both in experimental and clinical studies.[/box]
For additional research on ‘Cancer’ click here.
Source | GreenMedInfo