Scientists At Harvard Find Protein In Blood That Reverses Aging

Scientists At Harvard Find Protein In Blood That Reverses Aging

Two Harvard Stem Cell Institute (HSCI) researchers have identified a protein in the blood of mice and humans shaping up to be the first effective treatment for age-related heart failure affecting millions of Americans.

The protein, called GDF-11, was injected into old mice. Old mice, much like humans, develop thickened heart walls as they grow older.

The heart was reduced in size and thickness, resembling the healthy hearts of younger mice.

A finding by Richard T. Lee, a Harvard Medical School professor at Brigham and Women’s Hospital and Amy Wagers, a professor in Harvard’s Department of Stem Cell and Regenerative Biology, ultimately may rewrite our understanding of aging.

“The most common form of heart failure [in the elderly] is actually a form that’s not caused by heart attacks but is related to the heart aging,” said Lee.” In this study, we were able to show a protein circulating in the blood is related to the problem, and if we gave older mice this protein, we could reverse the heart aging in a short period.”

Scientists At Harvard Find Protein In Blood That Reverses Aging 1Lee said:

“We are excited because it opens a new window on the most common form of heart failure.” He added, “This is the coolest thing I’ve ever been a part of.”

Doug Melton, HSCI co-director and Harvard’s Xander University Professor, called the discovery “huge. It’s going to change the way we think about aging.

I have 300 patients right now, and I think I have about 20 who are suffering from this type of heart failure, which we sometimes call diastolic heart failure,” said Lee.

“They come into the hospital, have fluid taken off, then they’ll go home. Then they come back again. It’s frustrating because we don’t have any drugs to treat this. We need to work as hard as we can to figure out if this discovery can be turned into a treatment for heart failure in our aging patients.”

The Lee and Wagers labs now are focused on moving GDF-11 toward clinical trials which Lee predicts could begin in four to five years. More research may lead to learning what other tissue types the protein might affect.

“In this study, we compared young and old animals and identified a substance in the blood present at high levels when you’re young, and lower levels when you’re old.

We further found when we supplemented the low levels of this substance present in old animals to the levels normally seen in youth, this could have a dramatic effect on the heart. It’s been observed for many, many years that when aging occurs it affects multiple body system sort of in a semi-synchronous way,” Wagers said, “and this suggests there may be some common signal that drives the body’s response to getting older.

We hypothesized that this common signal might be a substance traveling in the bloodstream, because the bloodstream accesses organs throughout the body.”

Scientists At Harvard Find Protein In Blood That Reverses Aging  2ABSTRACTThe most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested the influence of circulating factors using heterochronic parabiosis, a surgical technique in which joining of animals of different ages leads to a shared circulation.

After 4 weeks of exposure to the circulation of young mice, cardiac hypertrophy in old mice dramatically regressed, accompanied by reduced cardiomyocyte size and molecular remodeling. Reversal of age-related hypertrophy wasn’t attributable to hemodynamic or behavioral effects of parabiosis, implicating a blood-borne factor.

Using modified aptamer-based proteomics, we identified the TGF-β superfamily member GDF11 as a circulating factor in young mice that declines with age. Treatment of old mice to restore GDF11 to youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy, revealing a therapeutic opportunity for cardiac aging.

For more information, check out the video below:

Sourceminds

Find us here

Get news from the CSGLOBE in your inbox each weekday morning

The views and opinions expressed in this article are those of the authors/source and do not necessarily reflect the position of CSGLOBE or its staff.

Paid content

Scientists Discover A Second Brain In Human Body, And It’s Located In The Butt

It turns out those gut feelings or pits in your stomach may actually come from your second...

First Ever Study of Unvaccinated Vs. Vaccinated Kids, Pulled from Journal, Erased from Internet

In recent years, the glaring spotlight of skepticism has been turned to the topic of vaccines, bitterly dividing parents and giving doctors of modern...

Harvard Study Proves Why The Bees Are All Disappearing

The human race is really starting to feel the consequences of their actions. One area we are waking up to is the massive amount...

What's New Today

Georgia House Votes To Allow Citizens To Abolish Police Departments In The State

The Georgia House backed an effort on Friday to dissolve the Glynn County Police Department and any...

Leaked CDC document contradicts Pence claim that U.S. coronavirus cases ‘have stabilized’

Even as Vice President Mike Pence wrote in a Wall Street Journal op-ed published Tuesday that coronavirus...

Five bombshells about Trump from Bolton ‘s book

Excerpts from former national security adviser John Bolton ’s book about his time in the Trump administration...

Don’t Listen to Fox. Here’s What’s Really Going On in Seattle’s Protest Zone.

It seems I live in a city undergoing a “totalitarian takeover” that will lead to “fascist outcomes”...

MOST READ

What Is Agenda 21? Depopulation of 95% of the World By 2030

Most people are unaware that one of the greatest threats to their freedom may be a United Nations program which plans to depopulate 95%...

Putin has Banned Rothschild and His New World Order Banking Cartel Family from Entering Russian Territory

As of recently, Russian president Vladimir Putin took yet another decision for his country. "Under any circumstances", the Rothschild family is banned from entering Russian territory. Along...

Alien Base for Giants Discovered in the Bucegi Mountains

In the summer of 2003, in an unexplored area of the Bucegi Mountains, a team from Zero Department (a top secret section of the...

Scientists Discover A Second Brain In Human Body, And It’s Located In The Butt

It turns out those gut feelings or pits in your stomach may actually come from your second...

Ingredient in Olive Oil Looks Promising in the Fight Against Cancer

Oleocanthal kills cancer cells with their own enzymes A Rutgers nutritional scientist and two cancer biologists at New York City’s Hunter College have found that...

“Killer Germs” Obliterated by Medicinal Smoke (Smudging), Study Reveals

The ritualistic use of plant smoke stretches back to the prehistorical era and is still used, the world over, as a way of 'cleansing'...

Scientists Accelerate Backward Time Travel Under Laboratory Conditions for First Time

In a first of its kind experiment, physicists from Washington State University have created the only known matter in the world with “negative mass.” Unlike every other physical object...

6 Manufactured Problems That Are Behind 6 Major Globalist Agendas

Problem-reaction-solution, the Hegelian Dialectic is that process the globalist ruling class have chosen to use as the primary tool to constantly change society in...

Russia’s Massive Tesla Tower Revealed in Drone Footage

Russia's Massive Tesla Tower Western energy sanctions levied against Russia are already threatening to trickle down and compromise the energy security of the entire EU,...

Ecuador’s Standing Rock is Happening Now – Can the World Save the Shuar?

With so much attention on this year on the struggle of the Standing Rock Sioux people in their opposition to the Dakota Access Pipeline...

3 Generations Were Asked The Same Question- What The Youngest Generation Answers Is Troubling

As part of a campaign hoping to inspire the rediscovery of nature (#RediscoverNature), Nature Valley asked three different generations the same question: What did/do you...